Welcome to the Perou Lab
Human carcinomas show great diversity in their morphologies, clinical histories and their responsiveness to therapy. This wide tumor diversity poses the main challenge to the effective treatment of cancer patients. The focus of my lab is to characterize the biological diversity of human tumors using genomics, genetics, and cell biology and to use this information to develop improved regimens that are specific for each tumor subtype, and for each patient. Our genomic characterization of human breast tumors identified the Intrinsic Subtypes of Breast Cancer that include Luminal A, Luminal B, Basal-like, HER2-enriched, and Claudin-low disease groups; these Intrinsic Subtypes are predictive of relapse-free and overall survival times and predictive of responsiveness to chemotherapy. In addition, we are performing similar genomic analyses of human lung and ovarian cancers as well as modeling these cancer types in mice. In summary, my lab utilizes a multi-disciplinary approach spanning cell biology, genomics, development, and computational approaches, to arrive at a detailed molecular model of the cancer cell that can be used as the basis for therapeutic decision making. I am actively seeking new graduate students, medical fellows and postdocs and have opportunities available for qualified scientists.